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Spectrophotometric Method for Determination of Meclizine in Pure and Dosage form Via Ion Pair Complex Formation Using Eosin Y

[ Vol. 14 , Issue. 2 ]

Author(s):

Majdi M. Bkhaitan* and Agha Z. Mirza   Pages 95 - 100 ( 6 )

Abstract:


Objective: Simple and sensitive UV method was developed and validated for the determination of meclizine hydrochloride in formulation, based on binary complex formation with eosin Y.

Method: The absorbance of the formed complex was measured at 540 nm. Beer's law was obeyed in the range of 5-25 µgmL-1 with r2 value 0.9960.

Results: The method showed good value of accuracy and precision (%RSD=1.096), and the limits of detection and quantification of the method were 0.76 and 2.29 µgmL-1, respectively. The analytical performance of the method was fully validated, and the results were satisfactory. The method can be applied successfully for the assay of meclizine hydrochloride in commercial tablets containing the drug alone or in combination.

Conclusion: This method provides a valid alternative of reported methods for the determination of meclizine in formulations as it's a simple, less time and cost consuming and can be applied for pharmaceutical analysis in pharmaceutical industries.

Keywords:

Meclizine hydrochloride, eosin Y, binary complex, spectrophotometric method, stoichiometry, ion-pairing.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy – Umm Al-Qura University, Makkah, Science and Technology Unit (STU), Umm Al-Qura University, Makkah

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