Differential Pulse Voltammetric Determination of Piroxicam on Lanthanide Ferric Oxide Nanoparticles-Carbon Paste Modified Electrode

Author(s):

Isaac Yves Lopes de Macedo, Morgana Fernandes Alecrim, Luane Ferreira Garcia, Aparecido Ribeiro de Souza, Wallans Torres Pio dos Santos, Eric de Souza Gil*, Laura M. Cubillana-Aguilera and Jose Maria Palacios-Santander*   Pages 271 - 276 ( 6 )

Abstract:

Introduction: Piroxicam (PRX) is a widely consumed anti-inflammatory drug, and the assays of its tablets and gels for quality control are mostly performed through High Performance Liquid Chromatography with Ultraviolet Detector (HPLC-UV).

Methods: In this regard, an alternate approach, LaFeO3 nanoparticles-modified carbon paste electrode was prepared in order to carry out PRX analysis by using voltammetric approaches.

Results: The modified electrode showed better analytical signal. The calibration curve is in the concentration range of 9.00 and 180.00 µmol·L-1 and the limit of detection was obtained as 1.00 µmol·L1 for PRX. The calculated recovery rate was fairly good (99.14%) in comparison with the declared value in the commercial product.

Conclusion: As shown by the low overall process cost, performance quickness and analytical results, the proposed method of electroanalysis with the LaFeO3 nanoparticles-modified carbon paste electrode presents a viable and interesting alternative approach to identification and determination of PRX compound in commercial products.

Keywords:

LaFeO3, nanoparticles, modified carbon paste electrode, electroanalysis, voltammetry, piroxicam, oxidation.

Affiliation:

Faculdade de Farmacia e Universidade Federal de Goias (UFG), Goiania – GO, Faculdade de Farmacia e Universidade Federal de Goias (UFG), Goiania – GO, Faculdade de Farmacia e Universidade Federal de Goias (UFG), Goiania – GO, Instituto de Quimica, Universidade Federal de Goias (UFG), Goiania – GO, Departamento de Farmacia - Universidade Federal dos Vales do Jequitinhonha e Mucuri, Campus JK, 39100-000, Diamantina - MG, Faculdade de Farmacia e Universidade Federal de Goias (UFG), Goiania – GO, Departamento de Quimica Analitica, Instituto Universitario de Investigacion en Microscopia Electronica y Materiales (IMEYMAT), Facultad de Ciencias, Universidad de Cadiz, Campus Universitario de Puerto Real, Poligono del Rio San Pedro S/N, 11510, Puerto Real, Cadiz, Departamento de Quimica Analitica, Instituto Universitario de Investigacion en Microscopia Electronica y Materiales (IMEYMAT), Facultad de Ciencias, Universidad de Cadiz, Campus Universitario de Puerto Real, Poligono del Rio San Pedro S/N, 11510, Puerto Real, Cadiz

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