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Simple and Rapid Determination of Paracetamol in Oral Pharmaceutical Preparations by a Home-use Glucometer for Paediatric Subministration

[ Vol. 14 , Issue. 4 ]

Author(s):

Ge Wang, Jing Zhu, Wei Wu* and Wei Zhang*   Pages 355 - 359 ( 5 )

Abstract:


Objective: A simple and rapid method for the measurement of paracetamol in oral pharmaceutical preparations by a commercial glucometer was proposed.

Methods: The established method was successfully applied to the determination of paracetamol in oral solid preparations, and exhibited the excellent capability of resisting interference from co-existing excipients. The commercial disposable test strips of hand-held glucometer showed high consistency of electrocatalytic activity toward the oxidation of paracetamol between each other.

Results: The linear range was from 0.2 mg/ml to 3.5 mg/ml with the detection limit of less than 0.2 mg/ml. The results demonstrated that the test strips can be used as a sensitive, selective and low-cost sensor for amperometric determination of paracetamol in oral solid dosage forms.

Conclusion: The unique application of household glucometer presented a convenient home-use tool for the paediatric subministration of the home medicine in common use.

Keywords:

Paracetamol, Glucometer, Paediatric subministration, Oral solid dosage form, Amperometric determination, Electrochemical sensor.

Affiliation:

Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004, Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004, Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004, Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004

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