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Synthesis and Biological Screening of N,N’-bis Disubstituted Adipic Acid Thioureas

[ Vol. 14 , Issue. 6 ]

Author(s):

Aneela Maalik, Sadia Hameed, Huma Aslam Bhatti, Abdur Rauf, Syed Majid Bukhari, Nighat Fatima, Hummera Rafique, Ehsan Ullah Mughal and Amara Mumtaz*   Pages 618 - 621 ( 4 )

Abstract:


Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction.

Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities.

Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.

Keywords:

Antimicrobial, antioxident, cytotoxic, thioureas, adipic acid thiourea, potassium thiocynate.

Affiliation:

Department of Chemistry, COMSATS Institute of Information Technology, 22060, Abbottabad, Department of Chemistry, COMSATS Institute of Information Technology, 22060, Abbottabad, Department of Chemistry, University of Swabi, Ambar-23561, Khyber Pakhtunkhwa, Department of Chemistry, University of Swabi, Ambar-23561, Khyber Pakhtunkhwa, Department of Chemistry, COMSATS Institute of Information Technology, 22060, Abbottabad, Department of Pharmacy, COMSATS Institute of Information Technology, 22060, Abbottabad, Department of Chemistry, University of Gujrat, Gujrat-50700, Department of Chemistry, University of Gujrat, Gujrat-50700, Department of Chemistry, COMSATS Institute of Information Technology, 22060, Abbottabad



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