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Synthesis and Biological Screening of N,N’-bis Disubstituted Adipic Acid Thioureas

[ Vol. 14 , Issue. 6 ]

Author(s):

Aneela Maalik*, Sadia Hameed, Huma Aslam Bhatti, Abdur Rauf, Syed Majid Bukhari, Nighat Fatima, Hummera Rafique, Ehsan Ullah Mughal and Amara Mumtaz*   Pages 618 - 621 ( 4 )

Abstract:


Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction.

Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities.

Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.

Keywords:

Antimicrobial, antioxident, cytotoxic, thioureas, adipic acid thiourea, potassium thiocynate.

Affiliation:

Department of Chemistry COMSATS University, 22060, Abbottabad Campus, Abbottabad, Department of Chemistry COMSATS University, 22060, Abbottabad Campus, Abbottabad, HEJ Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Department of Chemistry, University of Swabi, Ambar-23561, Khyber Pakhtunkhwa, Department of Chemistry COMSATS University, 22060, Abbottabad Campus, Abbottabad, Department of Pharmacy, COMSATS University, 22060, Abbottabad Campus, Abbottabad, Department of Chemistry, University of Gujrat, Gujrat-50700, Department of Chemistry, University of Gujrat, Gujrat-50700, Department of Chemistry COMSATS University, 22060, Abbottabad Campus, Abbottabad

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