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The Development and Validation of the Accurate and Sensitive HPLC Method for Quantification of Mizoribine in Human Plasma and Its Clinical Applications

[ Vol. 14 , Issue. 6 ]

Author(s):

Yanyan Wang, Fanlong Bu, Rui Zhang, Guiyan Yuan, Pingli Li, Xuwang Chen, Benjie Wang, Rong Li and Ruichen Guo*   Pages 541 - 546 ( 6 )

Abstract:


Background and Objectives: To establish a simple and reproducible High Performance Liquid Chromatography (HPLC) method for the determination of mizoribine in human plasma using glipizide as Internal Standard (IS).

Methods: The mizoribine in plasma was precipitated with 10% perchloric acid and separated on a Phenomenex Luna NH2 (250 mm

Keywords:

Mizoribine, HPLC, therapeutic drug monitoring, clinical, application, validation.

Affiliation:

Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan



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