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Overview of the Chromatographic and Mass Spectrometry Analytical Methods for Determination of Lamivudine in Biological Fluids

[ Vol. 15 , Issue. 2 ]

Author(s):

Xuwang Chen*, Fanlong Bu, Rong Li, Guiyan Yuan, Yanyan Wang and Benjie Wang   Pages 103 - 108 ( 6 )

Abstract:


Background: Lamivudine was approved by Food and Drug Administration of the United States for the treatment of both HIV and HBV infection, which has been widely used as monotherapy or a component of combination therapy in clinics in many countries and nationalities.

Methods: In this paper, the recent chromatographic and mass spectrometry analytical methods for the determination of lamivudine individually or combination with other drugs simultaneously were presented. These methods were widely applied in pharmacokinetics studies, bioequivalence studies, therapeutic drug monitoring studies, cell and animal experiments.

Conclusion: The review paper might provide references for determining lamivudine in biological fluids, the intracorporal process of lamivudine, and the clinical practice by monitoring plasma concentration of lamivudine in the future.

Keywords:

Lamivudine, biological fluids, chromatographic analysis, mass spectrometry analysis, HPLC, nucleoside ring.

Affiliation:

Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 107# West Culture Road, Jinan 250012, Shandong, Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 107# West Culture Road, Jinan 250012, Shandong, Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 107# West Culture Road, Jinan 250012, Shandong, Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 107# West Culture Road, Jinan 250012, Shandong, Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 107# West Culture Road, Jinan 250012, Shandong, Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 107# West Culture Road, Jinan 250012, Shandong



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