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Electrochemical Analysis of Antipsychotics

[ Vol. 15 , Issue. 5 ]

Author(s):

Leyla Karadurmus, Duru Kır, Sevinc Kurbanoglu* and Sibel A. Ozkan*   Pages 413 - 428 ( 16 )

Abstract:


Introduction: Schizophrenia is seizures accompanied by severe psychotic symptoms, and a steady state of continuation in the form of periods of stagnation. Antipsychotics are now the basis of treatment for schizophrenia and there is no other molecule that is antipsychotic priority in treatment. Antipsychotics can be classified into two groups; dopamine receptor antagonists such as promazine, fluphenazine etc. and serotonin-dopamine antagonists including risperidone, olanzapine, ziprasidone, aripiprazole etc.

Materials and Methods: Electrochemical methods have been used for the determination of antipsychotic agent just as used in the determination of many drug agents. Nearly all of the antipsychotics are electroactive and can be analyzed by electrochemical methods. Electroanalytical methods offer generally high sensitivity, are compatible with modern techniques, have low cost, low requirements, and compact design. Among the most commonly used types, there are cyclic voltammetry, differential pulse voltammetry, square wave voltammetry and linear sweep voltammetry.

Conclusion: The aim of this review is to evaluate the main line and the advantages and uses of electroanalytical methods that employed for the determination of antipsychotic medication agents used in schizophrenia. Moreover, applications of the methods to pharmaceutical analysis of Antipsychotics upto- date is also summarized in a table.

Keywords:

Electroanalytical methods, antipsychotic agents, drug analysis, voltammetry, Schizophrenia, seizures.

Affiliation:

Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara

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