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A Novel Simultaneous Estimation of Sofosbuvir and Velpatasvir in Human Plasma by Liquid Chromatography Tandem-Mass Spectrometry after Protein Precipitation Method

Author(s):

S. T. Narenderan, B. Babu*, T. Gokal and S. N. Meyyanathan   Pages 1 - 6 ( 6 )

Abstract:


Objective: The aim of the present work is to achieve a novel highly sensitive chromatographic method for the simultaneous determination of hepatitis C agents, sofosbuvir and velpatasvir from human plasma using ritonavir as an internal standard.

Method: Chromatographic separation was achieved using Hypersil C18 column (50mm x 4.6mm, 3

Keywords:

Hepatitis C, Human plasma, Sofosbuvir, Velpatasvir, US-FDA.

Affiliation:

JSS College of Pharmacy, Dept. of Pharmaceutical Analysis, JSS College of Pharmacy, Dept. of Pharmaceutical Analysis, JSS College of Pharmacy, Dept. of Pharmaceutical Analysis, JSS College of Pharmacy, Dept. of Pharmaceutical Analysis



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