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Rapid Electrochemical Ultra-Sensitive Evaluation and Determination of Daptomycin Based on Continuous Cyclic Voltammetry

[ Vol. 16 , Issue. 2 ]


Navid Rabiee, Moein Safarkhani and Mohammad Rabiee*   Pages 181 - 185 ( 5 )


Background: In this work, a novel and extra sensitive blood sample determination method for on-line monitoring of Daptomycin is represented.

Materials and Methods: This technique is in accordance with the electro-membrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV) coupling. Briefly, the potential waveform had become constantly utilized over a Gold Electrode and the electrode impulse was acquired by taking away the base current and developing the current in the particular potential area of oxidation of sample.

Results: This method was performed by utilizing a DC potential and migration of Daptomycin from the analyte fluid to the layer of 4-methyl-2-pentanol as well as following migration to the acceptor fluid.

Conclusion: A low and valuable detection limit of 3.5 ng ml-1 and quantification limit of 10.2 ng ml-1 are considered as a part of the sensible results of this experiment. Furthermore, efficient linearity in the range of 10.0-600 ng ml-1 was observed.


Daptomycin, electrochemical, rapid determination, continuous cyclic voltammetry, ultra-sensitive, resistance mechanisms.


Department of Chemistry, Shahid Beheshti University, Tehran, Department of Chemistry, Shahid Beheshti University, Tehran, Biomaterial Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran

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