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Rapid Electrochemical Ultra-Sensitive Evaluation and Determination of Daptomycin Based on Continuous Cyclic Voltammetry


Navid Rabiee, Moein Safarkhani and Mohammad Rabiee*   Pages 1 - 5 ( 5 )


In this work, a novel and extra sensitive blood sample determination method for on-line monitoring of Daptomycin is represented. This technique is in accordance with the electro-membrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV) coupling. Briefly, the potential waveform had become constantly utilized over a Gold Electrode and the electrode impulse was acquired by taking away the base current and developing the current in the particular potential area of oxidation of sample. This method was performed by utilizing a DC potential and migration of Daptomycin from the analyte fluid to the layer of 4-methyl-2-pentanol as well as following migration to the acceptor fluid. A low and valuable detection limit of 3.5 ng ml-1 and quantification limit of 10.2 ng ml-1 are considered as a part of the sensible results of this experiment. Furthermore, efficient linearity in the range of 10.0-600 ng ml-1 was observed .


Daptomycin, electrochemical, rapid determination, continuous cyclic voltammetry


Department of Chemistry, Shahid Beheshti University, Tehran, Department of Chemistry, Shahid Beheshti University, Tehran, Biomaterial Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran

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