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Evaluation of the Efficiency of Smart Stability-Indicating Spectrophotometric Methods Based on Mathematical and Statistical Processing of the Obtained Results Via Different Manipulating Pathways

Author(s):

Hayam Mahmoud Lofty, Yasmin Mohamed Fayez, Adel Magdy Michael and Christine Kamal Nessim*   Pages 1 - 15 ( 15 )

Abstract:


Background: Smart different stability-indicating spectrophotometric methods have been established for the assay of chlordiazepoxide and clidinium bromide without the intervention of alkaline degradate of clidinium via various and different manipulating pathways without previous separation steps. Method: These methods were employed either on scanned zero-order absorption spectra using absorbance subtraction, dual wavelength and Q-absorbance ratio or the amplitudes of the ratio spectra of zero-order absorption spectra like amplitude modulation and by derivative techniques to the ratio spectra as a derivative ratio method. In addition, the absorbance of the recovered zero-order absorption spectra was applied by successive ratio subtraction coupled with constant multiplication. Finally, the pathway depends on the amplitudes of the derivative spectra, successive derivative subtraction coupled with constant multiplication. The ranges of linearity were (1-12

Keywords:

Absorbance subtraction, Stability-indicating, Amplitude modulation, Successive derivative subtraction, Successive ratio subtraction, Dual wavelength, Q-absorbance ratio, Chlordiazepoxide, Clidinium bromid

Affiliation:

Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences & Pharmaceutical industries, Future University in Egypt, Cairo, Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Analytical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 12566, 6th of October City, Analytical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 12566, 6th of October City



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