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A Novel Potentiometric PVC-membrane Cysteamine-Selective Electrode Based on Cysteamine-Phosphomolybdate Ion-Pair

Author(s):

Merve Tumur, Gulsah Saydan Kanberoglu and Fatih Coldur*   Pages 1 - 8 ( 8 )

Abstract:


Background: Cysteamine is used as an orphan drug in the treatment of cystinosis to prevent long-term cystine accumulation in lysosomes. Dosing in cysteamine treatment is extremely important and overdose may cause some side effects. Up to now, various analytical methods have been used for cysteamine determination. Many of these methods require sophisticated instruments, expert operators, time-consuming measurement procedures and manipulation steps, expensive supplies and long analysis time. Aim and Objective: The present study deals with the development of a potentiometric PVC-membrane cysteamine-selective electrode based on an ion-pair of cysteamine and its application in a pharmaceutical formulation. Methods: Cysteamine (Cys)-Phosphomolybdate (PM) ion-pair was synthesized by mixing the equal volumes of 10-2 M Cysteamine HCl and sodium phosphomolybdate aqueous solutions. The obtained precipitate was used as ionophore in the structure of PVC-membrane. Results and Discussion: The electrode exhibited a linear response in the concentration range of 1.0

Keywords:

Cysteamine, cysteamine determination, drug analysis, potentiometry, ion-selective electrode, electrochemical sensor

Affiliation:

Institue of Science, Van Yuzuncu Yil University, Van, Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Department of Chemistry, Faculty of Arts and Sciences, Erzincan Binali Yildirim University, Erzincan



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