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A Comprehensive Review on Importance and Quantitation of Atypical Antipsychotic Drugs and Their Active Metabolites in Commercial Dosage Forms

Author(s):

Habibur Rahman, SK Manirul Haque* and Masoom Raza Siddiqui  

Abstract:


Background: Schizophrenia is one of the severe mental illness, affecting more than twenty one million people throughout the world which also causes early death in those people as compared to the normal one. Schizophrenia and other related psychotic ailments were cured by prescription of antipsychotic drugs, which act by blocking certain chemical receptor in the brain and thus relieve the symptoms of psychotic disorder. These drugs are present in the dosage forms in the market and provided in certain amount as per the need of the patients.

Objective: Since this kind of medication treats metal disorder, hence it is very important to have a perfect and accurate dose so that the risk factor is not affected by higher dose or lower dose, which is not sufficient for the treatment. For these different analytical methods were developed ranging from older spectrophotometric techniques to latest hyphenated methods.

Results: The current review highlights the role of different techniques that were employed in the determination and identification of the antipsychotic drugs and their metabolites. Analytical techniques such as spectrophotometry, fluorimetry, liquid chromatography, liquid chromatography- mass spectrometry, gas chromatography and gas chromatography- mass spectrometry employed in the method development of such antipsychotic drugs were reported in the review. Different metabolites were identified using the hyphenated techniques were also mentioned in the review. The synthesis pathways of few of the metabolites were mentioned.

Conclusion: The review summarizes the analyses of different antipsychotic drugs and their metabolites. A brief introduction of illness and their symptoms and possible medications were highlighted. Synthesis pathways of the associated metabolites were also mentioned.

Keywords:

Schizophrenia, antipsychotic drugs, analytical techniques, dosage forms, metabolites, hyphenated methods.

Affiliation:

Department of General Studies, Jubail Industrial College, P.O. Box No–10099, Zip Code–31961, Jubail, , Department of Chemical & Process Engineering Technology, Jubail Industrial College, P.O. Box No–10099, Zip Code–31961, Jubail,, Chemistry Department, College of Science, King Saud University, Riyadh 11451



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