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Voltammetric Method Development for Itopride Assay in a Pharmaceutical Formulation

Author(s):

Abdulaziz N. Amro*   Pages 1 - 7 ( 7 )

Abstract:


Background: Itopride used for the gastrointestinal symptoms caused by reduced gastrointestinal mobility. For the first time rapid, low cost and green voltammetric method has been applied to analyze itopride in pharmaceutical formulation.

Method: Cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods have been applied in this study.

Results: Na2SO4 (1M) supporting electrolyte exhibited sharper anodic peak current than other used supporting electrolytes; glassy carbon electrode (GC) working electrode shows better results than platinum electrode (Pt). SWV results show the lowest limit of detection and quantitation values of 2.3 and 18.1 µg.mL-1 respectively. SWV recovery is 100.56% and 100.46% for 50 µg.mL-1 and 100 µg.mL-1 of commercially available itopride tablets respectively. Furthermore SWV inter and intraday results precessions are better than other used methods with 0.96 and 0.56% RSD respectively.

Conclusion: The optimum method of applied methods in this study is SWV method. Voltammetry showed low LOD and LOQ values with high accuracy and precession in addition to comparable repeatability and reproducibility values.

Keywords:

Itopride, cyclic voltammetry, linear sweep voltammetry, square wave voltammetry, differential pulse voltammetry

Affiliation:

Chemistry Department- Faculty of Science, Taibah University,Al Madinah Al Munawwarah



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