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Analytical Techniques for the Estimation of Perindopril Erbumine: A Review

Author(s):

Mona Kaushal*, Khyati Pathak and Himani Patel   Pages 1 - 9 ( 9 )

Abstract:


Aims: According to Matthew R Alexander, MD, PhD Fellow, Division of Cardiovascular Medicine, Department of Internal Medicine, Physician Scientist Training Program, Vanderbilt University School of Medicine, have written in a article that an estimated 26% of the world’s population (972 million people) has hypertension, and the prevalence is expected to increase to 29% by 2025, driven largely by increases in economically developing nations. So many new drugs are developed for its treatment. Perindopril erbumine is a one of the ACE inhibitor for treating hypertension and heart failure.

Background: Perindopril is officially listed in USP, BP and EP. There are number of methods reported for its estimation.

Objective: Objective of this review article is to include various analytical techniques used for its estimation in bulk, dosage form or any bilological fluids.

Method: This paper includes various analytical techniques like UV-spectroscopic method, stability indicating liquid chromatography method, Thermo-Radio and Photo stability study, Stability indicating UHPLC-DAD method, LC-MS/MS electro spray ionization validated method, LC-MS/MS bio-analytical method, Thin layer chroamtography and many more.

Result: This paper has included all different analytical techniques used for estimation of Perindropril.

Conclusion: In this review, we summarized the analytical detection techniques used in identification, quantification of perindopril erbumine as well as its related substances. The Spectroscopy and RP-HPLC methods are widely applied for activity determination of perindopril erbumine as well as its related substances in pharmaceutical dosage forms. This all techniques can be precisely applied on Perindopril erbumine.

Other: There is still scope for the development of new selective and specific analytical techniques for quantization of this drug.

Keywords:

Angiotensin Converting Enzyme Inhibitor(ACE Inhibitor), Ultraviolet High Performance Liquid Chromatography- diode Array Detector method (UHPLC-DAD method), Liquid Chromatography-Mass Spectroscopy/Mass Spectroscophy (LC-MS/MS), Perindopril erbumine

Affiliation:

Quality Assurance Department, Arihant School Of Pharmacy And Bri, Uvarsad Cross Road, S. .G. Highway, Adalaj, Gandhinagar, Quality Assurance Department, Arihant School Of Pharmacy And Bri, Uvarsad Cross Road, S. .G. Highway, Adalaj, Gandhinagar, Quality Assurance Department, Arihant School Of Pharmacy And Bri, Uvarsad Cross Road, S. .G. Highway, Adalaj, Gandhinagar



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