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Analysis of Nonsteroidal Anti-inflammatory Drugs by using Microfluidic Techniques: A Review

[ Vol. 17 , Issue. 3 ]


Chiara Fanali, Giovanni D’Orazio, Alessandra Gentili and Salvatore Fanali*   Pages 303 - 315 ( 13 )


In this review paper, miniaturized techniques, including both electromigration and liquid chromatographic techniques, have been discussed considering their main features in the analytical field for the separation and analysis of Nonsteroidal Anti-inflammatory Drugs (NSAIDs). In Capillary Electrophoresis (CE) and nano-liquid chromatography (nano-LC), separation is performed in capillaries with Internal Diameter (I.D.) lower than 100 μm and therefore flow rates in the range 100-1000 nL/min are applied. Therefore, due to the low flow rate, high mass sensitivity can be obtained. Usually, conventional UV detectors are used on-line; however, these techniques can be coupled with Mass Spectrometry (MS). CE and nano-LC have also been applied to the separation of NSAIDs using silica stationary phases (SP) modified with C18 promoting interaction with analytes mainly based on hydrophobic interaction. Besides, the use of chiral SP was found to be effective for the chiral resolution of these compounds. In addition to silica phases, monolithic (both organic and inorganic) material has also been used. Although most of the presented studies aimed to demonstrate the usefulness of the considered microfluidic techniques, some applications to real samples have also been reported.


Nonsteroidal anti-inflammatory drugs, capillary zone electrophoresis, capillary liquid chromatography, nano-liquid chromatography, mass spectrometry, Liquid chromatography.


Faculty of Science, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Istituto per i Sistemi Biologici, Consiglio Nazionale delle Ricerche, Via Salaria km 29,300 - 00015 Monterotondo, Department of Chemistry, University of Rome “La Sapienza“, Piazzale Aldo Moro 5, P.O. Box 34, Posta 62, 00185 Roma, Teaching Committee of Ph.D. School in Natural Science and Engineering, University of Verona, Verona

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