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Analytical Methods Practiced to Quantitation of Rifampicin: A Captious Survey

Author(s):

Rajendra Muljibhai Kotadiya* and Foram Narottambhai Patel   Pages 1 - 17 ( 17 )

Abstract:


Background: Rifampicin (RIF), also known as rifampin, a bactericidal antibiotic having broad antibacterial activity against various gram-positive and gram-negative bacteria act by inhibiting DNA dependent RNA polymerase. RIF has been administered in different dosage forms like tablets, capsules, injections, oral suspension, powder etc. for the treatment of several types of bacterial infections, including tuberculosis, Mycobacterium avium complex, leprosy and Legionnaires’ disease.

Introduction: To ensure the quality, efficacy, safety and effectiveness of RIF drug product, effective and reliable analytical methods are utmost important. To quantify RIF for quality control or pharmacokinetic purposes, alternative analytical methods have been developed along with the official compendial methods. Method: In this review paper, an extensive literature survey was done to gather information on various analytical instrumental methods used so far for RIF.

Result: These methods were high-performance liquid chromatography (42%), hyphenated techniques (18%), spectroscopy (15%), high-performance thin-layer chromatography or thin-layer chromatography (7%) and miscellaneous (18%). Conclusion: All these methods were selective and specific for the RIF analysis.

Keywords:

RIF, analytical method, chromatography, spectrophotometer, C18 column, reverse phase

Affiliation:

Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Dist. Anand, Gujarat, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Dist. Anand, Gujarat



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