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Determination of Pharmaceuticals by UV-Visible Spectrophotometry

Author(s):

Avvaru Praveen Kumar* and Deepak Kumar   Pages 1 - 15 ( 15 )

Abstract:


Pharmaceuticals are the chemical molecules which invented to improve the life of living things through diagnosing, curing, treating or preventing diseases. Pharmaceuticals can do their maximum function or work against disease or prevent from harmful effects of diseases only if they are free from impurities. The pharmaceutical analysis consists of different essential and important procedures to ascertain “identity, strength, quality and purity” of drug molecules. There are three different possibilities to originate impurities which include (i) at the developmental stages of pharmaceuticals, (ii) at the time of transportation, and (iii) storage conditions. So, the pharmaceuticals must be examined at all stages and the impurities should be discovered and quantified. Pharmaceutical analysis also admits analysis of intermediates and raw materials during synthesis of drug molecules. Instrumentation is required to perform pharmaceutical analysis and methods can be developed to certain required levels. This review affords basic theory of UV-Visible spectrophotometry and its applications, pharmaceutical method development and validation, and a list of some reported spectrophotometric methods which are employed in pharmaceutical analysis during 2011 to 2020.

Keywords:

Pharmaceuticals, Analysis, Method development, Method validation, Spectrophotometry, Applications.

Affiliation:

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, PO Box 1888, Adama, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Bajhol, Solan-(H.P)-173229



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