Iram Kaukab, Syed Nisar Hussain Shah and Ghulam Murtaza* Pages 703 - 709 ( 7 )
Background: Metoclopramide is a potent dopaminergic antagonist utilized for treating gastrointestinal disorders. The aim of this study was to examine the pharmacokinetics of oral formulation of metoclopramide in the Pakistani volunteers.
Methods: This open label, single dose, pharmacokinetic study was executed in non-smoking, 12 Pakistani healthy males, treated with a single 20 mg oral tablet dose of metoclopramide on test day. Maximum plasma concentration (Cmax), time to achieve Cmax (Tmax), and area under curve (AUC0-t) of metoclopramide were determined analyzing the serial blood samples using a validated HPLC-UV method.
Results: The determined values of Cmax, Tmax, and AUC0-t of metoclopramide were 34.51 ± 4.91 ng/ml, 1.56 ± 0.18 and 273.88 ± 114.49 ng.h/ml, respectively.
Conclusion: The results reveal that the findings of Pakistani individuals are slightly different when compared with the published data of other ethnic origins.
Metoclopramide hydrochloride, High Performance Liquid Chromatography (HPLC), pharmacokinetic study, method development, protein precipitation, validation.
Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060