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Single Dose Pharmacokinetics of Metoclopramide Oral Tablets Utilizing HPLC-UV Method

[ Vol. 15 , Issue. 7 ]

Author(s):

Iram Kaukab, Syed Nisar Hussain Shah and Ghulam Murtaza*   Pages 703 - 709 ( 7 )

Abstract:


Background: Metoclopramide is a potent dopaminergic antagonist utilized for treating gastrointestinal disorders. The aim of this study was to examine the pharmacokinetics of oral formulation of metoclopramide in the Pakistani volunteers.

Methods: This open label, single dose, pharmacokinetic study was executed in non-smoking, 12 Pakistani healthy males, treated with a single 20 mg oral tablet dose of metoclopramide on test day. Maximum plasma concentration (Cmax), time to achieve Cmax (Tmax), and area under curve (AUC0-t) of metoclopramide were determined analyzing the serial blood samples using a validated HPLC-UV method.

Results: The determined values of Cmax, Tmax, and AUC0-t of metoclopramide were 34.51 ± 4.91 ng/ml, 1.56 ± 0.18 and 273.88 ± 114.49 ng.h/ml, respectively.

Conclusion: The results reveal that the findings of Pakistani individuals are slightly different when compared with the published data of other ethnic origins.

Keywords:

Metoclopramide hydrochloride, High Performance Liquid Chromatography (HPLC), pharmacokinetic study, method development, protein precipitation, validation.

Affiliation:

Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060

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