Igor R. Santos Magalhaes and Pierina S. Bonato Pages 15 - 29 ( 15 )
The majority of the drugs currently employed in the treatment and prophylaxis of malaria are chiral and show enantioselective pharmacodynamic and pharmacokinetic properties in humans and animals. Thus, the assessment of the disposition of these enantiomers in the body using reliable and feasible methods is required to improve the therapy of this disease. Several methods devoted to the enantioselective analysis of the antimalarial drugs and their respective metabolites have been described. Therefore, this article intends to review the methods reported for the enantioselective determination of these analytes with a focus on biological matrices and particular attention will be given to the modern techniques of analysis and sample preparation.
Antimalarial drugs, Enantioselective analysis, Sample preparation, Biological matrices
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe S/N, 14040-903, Ribeirao Preto, SP, Brazil.